background • Ovarian cancer is the 8th most common cancer among women in Lebanon. Despite new advances in the treatment of these tumors, their prognosis remains very poor. the histology of ovarian tumors and their stage at the time of diagnosis are the two most relevant prognostic factors. Epithelial tumors, including serous, mucinous, endometrioid, clear-cell, Brenner and seromucinous tumors, account for the vast majority of ovarian tumors. Germ cell tumors and tumors of the sexual cord are respectively the second and third subgroups of ovarian tumors. In Lebanon, there are no data concerning borderline and malignant ovarian tumors. Aim • we report the epidemiological and histological characteristics of borderline and malignant ovarian tumors in a Lebanese tertiary hospital.

Material and Methods • this is a retrospective study evaluating the characteristics of borderline and malignant ovarian tumors diagnosed in 19 years (from 1999 to 2017) at the pathology laboratory of hôtel-Dieu de France, Saint Joseph University hospital in Beirut, Lebanon. the data were extracted from the computerized registers of the laboratory. Statistical analysis was performed using SPSS 24.0. Results• A total of 996 ovarian lesions were found. Of these, 529 [53.1%] were epithelial (342 [64.7%] serous, 107 [20.2%] mucinous, 23 [4.3%] endometrioid, 18 [3.4%] undifferentiated carcinoma, 15 [2.8%] seromucinous, 12 [2.3%] clear cell and 12 [2.5%] Brenner); 285 [28.6%] were germinal (including 245 [86.0%] mature teratomas, 12 [4.9%] dysgerminomas and 7 [2.5%] immature teratomas); 83 (8.3%) were stromal tumors of the sexual cord. Of the 529 epithelial tumors, 261 [49.3%] were benign (60% were serous cystadenomas), 46 [8.7%] were borderline (26 serous, 18 mucinous and 2 serous) and 222 [42.0%] were malignant (of which 139 [62.6%] were high grade serous carcinomas, 19 [8.6%] endometrioid, 18 undifferentiated, 12 low-grade serous and 12 clear cell). Mean age for malignant epithelial tumors and borderline epithelial tumors were 54.3 years and 39.7 years respectively.

Conclusion • Our data are compatible with those published in western countries. Many studies will be launched on the basis of this database, including the evaluation of somatic and germinal ovarian panel mutations in high-grade ovarian serous carcinoma and in those with borderline tumor sequencing.

Keywords : ovarian cancers; somatic and germinal mutations; borberline; malignant tumors

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