background • Pancreatic adenocarcinoma (PAC) forms 85% of pancreatic cancers. In Lebanon the annual mortality rate is 4.3 per 100 000 persons. Data are lacking in the Lebanese population on the treatment evolution of pancreatic adenocarcinoma. we conducted a study to compare two groups of pancreatic adenocarcinoma patients through time.

Methods • we randomly assigned 70 patients from NDS-Uh who were diagnosed having PAC from the beginning of the year 2000 until the end of 2017. All patients were above 18 years old at time of diagnosis, with an ECOG PS of 0 or 1. All of them had not received any prior chemotherapy or radiotherapy, and they all had a locally advanced i.e. inoperable or metastatic PAC. the 70 patients were divided into 2 groups. the first group is formed by all patients diagnosed before 2010 and the second group by all patients diagnosed after 2010. the primary endpoint is the OS rate in each group. the secondary endpoints are the PFS1, PFS2, RR and the mean OS variability in each gender with time.