Volume 70 (2023) Issue 1

Since it is one of the most crucial quality control tests carried out on pharmaceutical dosage forms and is currently turning into a tool for prediction, most research have employed dissolving test. bioavailability, and occasionally substituting clinical research to establish bioequivalence. Drug pharmacological action is substantially influenced by their dissolution behavior. Actually, it has been shown and usually referred to as in vitro-in vivo correlation, IVIVC, a direct association between in vitro dissolution rate of several medications and their bioavailability. We tried to gather numerous studies and profit from past experiences in an attempt to investigate the possible alterations that might increase the bioavailability of aspirin, lower gastrointestinal side effect and offer a fast effect in our study. Our investigation was planned practically, and the cornerstone of our approach was a dissolution test. The course of research was altered during the COVID-19 epidemic to a theoretical review. The aim of the study is to provide prospective studies with the necessary information that reflect the effect of formulation changes on the in vivo performance by means of excipients and dosage form formulations, so exploring, in a comparative manner, their impact on aspirin’s dissolution rate.

Background: Lack of adherence to anti-diabetic drugs is related with poor glycemic-control and sub-optimal profits from their given drugs which causes insignificant control of blood sugar between diabetic patients and can result in failure of treatment, enhanced development of complications and augmented mortality. Objective: The following study aimed to evaluate adherence to antidiabetic drugs among diabetic patients and associated factors in Annajaf Community-Iraq. Methods: A “cross sectional study” was conducted among 380 diabetic patients at Al-Hakeem center for diabetic patients at Annajaf governorate in Iraqi. The patients ages were ≤18 years who have been administered anti-diabetic medication for as a minimum three months. Pretested questionnaires have been used. Variables that have been gathered were covered socio-demographic characteristics. Adherence was assessed the usage of Iraqi anti-diabetic medicine adherence scale. Inferential and descriptive statistic have been analyzed achieved to calculate adherence level to anti-diabetic drugs and the related factors. Results: The level of adherence to anti-diabetic drugs was 71.8% whom highly adherent, while non-adherent [intermediate adherence was 84(22.1%) and low adherence 23(6.1%)]. When univariate analysis was done, the age, smoking status, life style, type of antidiabetic, HbA1C, education, duration of Disease, and no. of comorbidities were showed chi-squared test statistical significance with level of adherence, while by multivariate analysis, the type of antidiabetic, education, and no. of comorbidities were showed statistical significance with level of adherence. Conclusion: About three in each four patients were well adherent to anti-diabetic therapy. Many strategies designed to refining the availability of anti-diabetic medications and supplying health education which might increase the adherence level.